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The core Genomic Sciences Faculty is listed with their departmental affiliations and research interests.
Kenneth
B. Adler
Professor, Department of Molecular Biomedical Sciences
Research Interests: Inflammatory mediators, signal transduction in airway epithelia
Paul F. Agris
Professor, Department of Molecular & Structural Biochemistry
Research Interests: Nucleic acid design; molecular biology; biophysics
George Allen
Research Assistant Professor, Crop Science
Research Interest: Higher-order structure of plant nuclei; effects of chromatin structure and nuclear position on plant gene expression and gene silencing
Jose M. Alonso
Assistant Professor, Department of Genetics
Research Interests: Signal transduction and functional genomics in Arabidopsis
Henry V. Amerson
Associate Professor, Department of Forestry & Environmental Resources
Research Interests: Forest pathology; genetic basis for resistance to fusiform rust disease in loblolly pine
Robert R.H. Anholt
William Neal Reynolds Professor, Department of Zoology
Research Interests: Molecular neurobiology of olfaction; functional genomics of olfactory behavior; characterization of the olfactomedin gene family
Prema Arasu
Associate Professor, Department of Molecular Biomedical Sciences
Research
Interests: Molecular analyses of host-parasite interactions;
reactivation of latent infections during pregnancy
Chris Ashwell
Assistant Professor, Department of Poultry Science
Research Interests: Studying the genetic basis for immune response; nutritional and developmental traits in domestic poultry species utilizing QTL mapping and gene expression analysis techniques.
Melissa Ashwell
Assistant Professor, Department of Animal Science
Research Interests: Using genomics tools to identify quantitative trait loci and study genes affecting production, health, and reproduction in livestock species
William R. Atchley
William Neal Reynolds Professor, Department of Genetics
Research Interests: Developmental quantitative genetics and molecular evolution
Jill Barnes
Assistant Professor, Department of Molecular Biomedical Sciences
Research Interests: Stress protein expression; cell growth and cytoprotection; breast cancer
David McK. Bird
Professor, Department of Plant Pathology
Research Interests: The mechanism of parasitism in nematodes using genetic; genomic, molecular and cell biology approaches
Donald L. Bitzer
Distinguished University Research Professor, Department of Computer Science
Research Interests: Application of Information Theory to genetics; ribosome memory and signal processing; free energy calculations for genetic sequences; optimization of cross-species translation
Russell Borski
Professor, Department of Zoology
Research Interests: Functional genomics and endocrinology of growth and osmoregulation in vertebrates
Wendy Boss
William Neal Reynolds Professor, Department of Plant Biology
Research Interests: The function of inositol phospholipids in regulating plant perceptions and responses to environmental stimuli
Rebecca S. Boston
William Neal Reynolds Distinguished Professor, Department of Plant Biology
Research Interests: Protein-pathogen relationships of maize ribosome-inactivating proteins and value-added products in crop plants
Matthew Breen
Professor, Department of Molecular Biomedical Sciences
Research Interests: Canine and equine genome maps; canine and human cancers; comparative genomics; chromosome evolution
Edward B. Breitschwerdt
Professor of Medicine and Infectious Diseases, Department of Clinical Sciences
Research Interests: The molecular pathogenesis of vector-transmitted intercellular pathogens in the genera Ehrlichia, Rickettsia and Bartonella
Brenda Judge Brizuela
Assistant Professor, Department of Zoology
Research Interests: Developmental biology of vertebrates: the role of tight junctions in epithelial morphogenesis and organ formation using the frog Xenopus leavis as a model system
Dennis T. Brown
Professor, Department of Biochemistry
Research Interests: Structure, function and assembly of the model membrane-containing virus Sindbis
James W. Brown
Associate Professor, Department of Microbiology
Research Interests: RNA structure and function; microbial diversity; molecular evolution
Ignazio Carbone
Assistant Professor, Department of Plant Pathology
Research Interests: Evolution of genetic and phenotypic variation in natural fungal populations; statistical analysis of population processes as they affect phylogeography, conservation biology and epidemiology
Joe Cassady
Assistant Professor, Department of Animal Science
Research Interests: Functional and quantitative genomics relative to food animal production. Primary species of interest are pigs and beef cattle
John Cavanagh
William Neal Reynolds Professor, Department of Molecular & Structural Biochemistry
Research Interests: Structure, dynamics, and interactions of proteins involved in bacterial protection and competence using high resolution NMR and mass spectrometry
Vincent Chiang
Professor, Department of Forestry & Environmental Resources
Research Interests: Functional genomics of lignin, cellulose and hemicellulose biosynthesis and carbon sequestration in wood formation; regulatory functions of RNA; tree tissue culture; forest biotechnology
A. Clay Clark
Associate Professor, Department of Biochemistry
Research Interests: Protein folding and assembly; protein interactions; mechanisms of molecular chaperones in protein folding
Steven D. Clouse
Professor, Department of Horticultural Science
Research Interests: Regulation of plant gene expression during development;
molecular mechanisms of plant hormone action, particularly brassinosteroids; functional genomics, including microarrays
Stephanie E. Curtis
Professor, Department of Genetics
Research Interests: Regulation of gene expression during cyanobacterial development
Margaret E. Daub
William Neal Reynolds Professor, Department of Plant Biology
Research Interests: Fungal molecular genetics; toxins in plant pathogenesis; active oxygen and cellular oxidative stress resistance; plant transformation
Marie Davidian
Professor, Department of Statistics
Research Interests: Hierarchical nonlinear models, covariate measurement error and missing data in these models; analysis of assay data and calibration
Gregg A. Dean
Professor, Department of Molecular Biomedical Sciences
Research Interests: The immunopathogenesis of Feline Immunodeficiency Virus (FIV) and the development of rational vaccine strategies that may be applied across species
Ralph A. Dean
Professor, Department of Plant Pathology
Research Interests: Molecular basis of fungal infection of plants; fungal genomics; fungal development
Ralph E. Dewey
Associate Professor, Department of Crop Science
Research Interests: Molecular biological approaches to identify and isolate agronomically important genes (tobacco variability, soybean seed storage oils)
Meg Ehm
Adjunct Assistant Professor, Department of Statistics
Research Interests: Genetics and bioinformatics
Patricia Estes
Research Assistant Professor, Department of Genetics
Research Interests: Development of the central nervous system in Drosophila; differential gene expression during development
Charlotte Farin
Professor, Department of Animal Science
Research Interests: Molecular mechanisms controlling meiotic maturation of bovine oocytes; gene expression and control of preimplantation development of bovine embryos; improvement of bovine in vitro fertilization systems; analysis of development of in vitro produced bovine fetuses
John Frampton
Associate Professor, Department of Forestry & Environmental Resources
Research Interests: Christmas tree and Fraser fir genetics; use of clones in forest tree species; host-pathogen interactions in forest diseases
Robert G. Franks
Assistant Professor, Department of Genetics
Research Interests: Control of cellular division and patterning events during the development of the Arabidopsis seed pod; control of floral organ size and shape in Arabidopsis
Frederick J. Fuller
Professor, Department of Population Health & Pathobiology
Research Interests: The interaction between the equine infectious anemia retrovirus and the monocytes/macrophages that it infects
John E. Gadsby
Professor, Department of Molecular Biomedical Sciences
Research Interests: Growth factor regulation of ovarian function
Sujit K. Ghosh
Professor, Department of Statistics
Research Interests: Statistical modeling of survival and spatial data using Bayesian Markov Chain Monte Carlo (MCMC) methods
John Godwin
Associate Professor, Department of Zoology
Research Interests: Molecular endocrinology, neurobiology, and behavior with a primary focus on the mechanisms and evolution of animal sexuality
Barry Goldfarb
Professor, Department of Forestry & Environmental Resources
Research Interests: Molecular basis of plant development; adventitious root initiation in pine cuttings; rooted-cutting technology for improvement of southern pines
Major M. Goodman
William Neal Reynolds Distinguished University Professor, Department of Crop
Science
Research Interests: isozyme genetics; evolution of cultivated plants; numerical taxonomy; plant breeding
Michael B. Goshe
Assistant Professor, Department of Molecular & Structural Biochemistry
Research Interests: Biological mass spectrometry applications and method development for proteomics, post-translational site mapping, and characterizing protein-protein, protein-nucleic acid, and protein-ligand interactions
Christina M. Grozinger
Assistant Professor, Department of Entomology
Research Interests: Neurogenomics of pheromone-mediated behavior in honey bees; functional genomics of reproductive and post-mating behavioral changes
Amy M. Grunden
Assistant Professor, Department of Microbiology
Research Interests: Physiology and metabolic regulation of hyperthermophiles; expression of hyperthermophilic proteins
Linda K. Hanley-Bowdoin
William Neal Reynolds Distinguished Professor, Department of Biochemistry
Research Interests: Geminiviruses as models for plant DNA replication, transcription and cell cycle regulation
Jason M. Haugh
Associate Professor, Department of Chemical Engineering
Research Interests: Cell engineering; quantitative analysis
and mathematical modeling of intracellular signal transduction
networks
Steffen Heber
Assistant Professor, Department of Computer Science
Research Interests: Expressed sequence tag assembly; transcript analysis and alternative splicing; gene order permutations
Cynthia L. Hemenway
Associate Professor, Department of Biochemistry
Research Interests: Plant virus; RNA replication; transgenic plants
James Holland
USDA-ARS Research Geneticist and Professor, Department of Crop Science
Research Interests: Genomics-assisted maize breeding and quantitative genetics
Jon Horowitz
Associate Professor, Department of Molecular Biomedical Sciences
Research Interests: Regulation of the Sp-family of transcription factors by Rb, Rb-binding proteins and novel dimerization partners of E2F/DP proteins
Jacqueline Hughes-Oliver
Professor, Department of Statistics
Research Interests: Point source modeling; spatial statistics; drug discovery; covariance nonstationarity group testing; optimal design of experiments; nonlinear models; industrial statistics
Fikret Isik
Research Assistant Professor, Department of Forestry & Environmental Resources
Research Interests: Quantitative genetics; conifer breeding; inheritance of economically important traits in conifer breeding populations; general and generalized linear mixed models genetic data analysis; genetic basis of disease resistance in forest trees; design & analysis of expression experiments; association genetics using SNP markers
Erich L. Kaltofen
Professor, Department of Mathematics
Research Interests: Symbolic computation
Norman Kaplan
Adjunct
Professor, Department of Statistics / NIEHS
Research Interests: Family based tests for linkage and association between marker and disease loci
Sophia Kathariou
Associate Professor, Department of Food Science
Research Interests: Virulence, adaptive physiology, ecology, molecular
epidemiology and evolution of bacterial foodborne pathogens
Robert
M. Kelly
Professor,
Department of Chemical Engineering
Research
Interests: Physiology, enzymology and biotechnological potential
of hyperthermophilic microorganisms
Todd
R. Klaenhammer
William Neal Reynolds Distinguished University Professor, Department of Food, Bioprocessing & Nutrition Sciences
Research
Interests: Genomic investigation and genetic modification of
food-borne lactic acid bacteria used in fermentation bioprocessing,
bio-delivery, and as probiotics
Matthew
Koci
Assistant
Professor, Department of Poultry Science
Research
Interests: Molecular and cellular mechanisms of viral pathogenesis,
enteric viruses, molecular determinants of virulence, innate
resistance to viral infection, functional and comparative
immunity; discovery of resistance genes in avian species
David
Lalush
Associate Professor, Department of Biomedical Engineering
Research
Interests: In vivo functional and anatomical imaging of small
animals; in vivo imaging of gene expressions; molecular imaging
of engineered tissues; microarray data analysis
Steven
Leath
Associate
Dean and Director, NC Agricultural Research Service
Research
Interests: Introgression of disease resistance genes into hexaploid
wheat; mapping of resistance genes; identification and use of
markers to combine resistance genes for enhanced phenotypic
expression of resistance
David
H. Ley
Professor,
Department of Population Health & Pathobiology
Research
Interests: Pathophysiology of avian mycoplasma infections, esp.
M. gallisepticum and M. synoviae with objectives to improve
serologic and organism detection diagnostic tests and explore
new methods of treatment and prevention including antimicrobics
and vaccines.
Bailian
Li
Vice Provost for International Affairs, Office of International Affairs
Research
Interests: Forest genetics and breeding; genetic data analysis
and interpretation; genetic studies of tree physiology and molecular
biology
Laigeng
Li
Research
Associate Professor, Department of Forestry & Environmental Resources
Research
Interests: Molecular biology of cell wall biosynthesis, concentrating
on lignin and cellulose biosynthesis; funtional genomics of
xylem development in trees; and tree biotechnology
Lexin Li
Assistant Professor, Department of Statistics
Research
Interests: sufficient dimension reduction, bioinformatics and computational biology, machine learning and data mining, biostatistics
Jonathan
S. Lindsey
Glaxo
Distinguished University Professor, Department of Chemistry
Research
Interests: Development of synthetic methods in porphyrin chemistry;
design of molecular photonic devices for studies in artificial
photosynthesis and molecular photonics; development of workstations
for automated chemistry
Ben-Hui
Liu
Associate
Professor, Department of Forestry & Environmental Resources
Research
Interests: Applied genomics; genome informatics; biochip-related
technology development; and functional genomics
Hsiao-Ching
Liu
Assistant
Professor, Department of Animal Science
Research
Interests: Viral-host interactions, finding genetic factors
involved pathogenesis and host disease resistance
Steven
A. Lommel
William Neal Reynolds Professor,
Department of Plant Pathology
Research
Interests: Host-pathogen interactions, mechanisms of disease
induction in plant viruses and systemic infection
Jane
L. Lubischer
Assistant
Professor, Department of Zoology
Research
Interests: Developmental neurobiology, neural response to injury
Trudy
F. C. Mackay
William
Neal Reynolds Professor, Department of Genetics
Research
Interests: The genetic basis of quantitative variation
James
W. Mahaffey
Associate
Professor, Department of Genetics
Research
Interests: Animal development - specification of body pattern
Linda
Martin
Assistant
Professor, Department of Molecular Biomedical
Sciences
Research
Interests: Inflammatory respiratory disease; oxidant-regulated
gene expression; signal transduction, cellular differentiation
and development of pathogenic lesions in airway epithelia
Laura
Mathies
Assistant
Professor, Department of Genetics
Research
Interests: Molecular and genetic controls of animal development:
organ formation in the nematode C. elegans
Carla
Mattos
Associate
Professor, Department of Molecular and Structural Biochemistry
Research
Interests: Structural analysis of the complete binding surfaces
of small monomeric GTPases
E. Stuart Maxwell
Professor,
Department of Molecular & Structural Biochemistry
Research
Interests: Biosynthesis, structure and function of small nucleolar
RNAs (snoRNAs); eukaryotic snoRNP/archaeal sRNP structure; snoRNA
guided nucleotide modification and ribosome biogenesis
Steve
McKeand
Professor,
Department of Forestry & Environmental Resources
Research
Interests: Genetic effects on ecophysiological processes in
forest trees, biotechnology/breeding interface, seed orchard
management, and genotype by environment interactions
W. Owen McMillan
Associate
Professor, Department of Genetics
Research
Interests: Genetic and developmental architecture of adaptive variation; population and conservation genetics
Eric
S. Miller
Professor, Department of Microbiology
Research
Interests: RNA-Protein interactions, bacteriophage and microbial
products
Alison Motsinger-Reif
Assistant Professor,
Department of Statistics
Research
Interests: Computational methods to detect gene-gene and gene-environment interactions that predicit complex human phenotypes in high-throughput data
James
W. Moyer
Professor,
Department of Plant Pathology
Research
Interests: Investigations of the evolution and genetics of tospoviruses
(Bunyaviridae) as each relates to viral adaptation to resistant
hosts and a second area on development of tools for marker assisted
breeding of floral crops
Paul
Mozdziak
Associate
Professor, Department of Poultry Science
Research
Interests: The cellular and molecular mechanisms governing skeletal
muscle growth and muscle adaptation; mechanisms governing myonuclear accretion
David
C. Muddiman
Professor,
Department of Chemistry
Research
Interests: Proteomics measurements to understand disease processes;
bioinformatic & statistical analysis of complex data set;
data visualization
Spencer
V. Muse
Assistant
Professor, Department of Statistics
Research
Interests: Statistical methods for the analyses of DNA sequence
data, with emphasis on molecular evolutionary analyses
Dahlia
Nielsen
Research
Assistant Professor, Department of Genetics
Research
Interests: Statistical Genetics
Jack
Odle
William
Neal Reynolds Professor, Department of Animal Science
Research
Interests: Molecular and biochemical regulation of lipid digestion
and metabolism; molecular mechanisms undergirding intestinal
growth and metabolism during healthy and diseased states; piglet
model of neonatal
metabolism
Jonathan
Olson
Assistant
Professor, Department of Microbiology
Research
Interests: Bacterial physiology, especially inorganic respiratory
substrates of food-borne pathogens
Charles
H. Opperman
Professor,
Department of Plant Pathology
Research
Interests: Plant-parasitic nematode genetics; molecular crop
protection
Paul
E. Orndorff
Professor, Department of Population Health & Pathobiology
Research
Interests: Genetics of virulence in bacteria
Gary
A. Payne
William Neal Reynolds Professor,
Department of Plant Pathology
Research
Interests: Molecular genetics of secondary metabolism in filamentous
fungi and plant resistance to seed pathogens
Ilenys M. Perez-Diaz
Associate
Professor, Department of Food, Bioprocessing & Nutrition Sciences
Research
Interests: Development of rapid identification methods for lactic acid bacteria present in fresh and fermented cucumbers; improved techniques to prevent the growth of spoilage microorganisms and assure inactivation of pathogenic bacteria in acidified vegetable products
James
Petitte
Associate
Professor, Department of Poultry Science
Research
Interests: Germ cell development; avian transgenics; early avian
development
Robert
M. Petters
Professor,
Department of Animal Science
Research
Interests: Reproductive physiology and genetics; embryo development
in vitro; embryo micromanipulation; genetic engineering; biomedical
models of human disease
Jorge
Piedrahita
Professor, Department of Molecular Biomedical Sciences
Research
interests: Transgenic animal development (mice, pigs, cattle)
for use in human and veterinary medicine and in agriculture
Jean
B. Ristaino
Professor,
Department of Plant Pathology
Research
Interests: Development of PCR-based markers to fingerprint individual
species in the fungal genus Phytophthora; development
of alternatives to pesticides for management of soilborne pathogens
Dominique
Robertson
Professor, Department of Plant Biology
Research
Interests: Geminivirus-mediated gene silencing for the functional
analysis of plant genes; cell biology of viral DNA replication
in plants
Marcelo
L. Rodriguez-Puebla
Assistant
Professor, Department of Molecular Biomedical Sciences
Research
Interests: Regulation of normal and neoplastic proliferation
by cyclin-dependent
kinase proteins in epithelial tissues; transgenic and knockout
mice to study the cell-cycle regulation
Celeste
Sagui
Assistant
Professor, Department of Physics
Research
Interests: Molecular dynamics simulations of biomolecules
Heike Winter Sederoff
Assistant Professor, Plant Biology
Research
Interests: Plant sensory genomics; plant systems biology; molecular basis of root responses to light, gravity, and mechanical stress; metabolic engineering in tomato
Ronald
R. Sederoff
Edwin F. Conger Distinguished University Professor, Department of Forestry & Environmental Resources
Research
Interests: Molecular genetics and genomic mapping of forest
trees (accelerated breeding, disease resistance, modification
of wood properties); focus on loblolly pine
Barbara
Sherry
Professor, Department of Molecular Biomedical Sciences
Research
Interests: Viral infection of the heart and cardiac antiviral
responses including interferon; molecular approaches using primary
cardiac myocyte cultures
Michael
Sikes
Assistant
Professor, Department of Microbiology
Research
Interests: Regulatory mechanisms that control the recombination
of antigen receptor genes in developing lymphocytes. Approaches
include molecular genetic and epigenetic manipulation of recombining
gene segments
Robert
C. Smart
Professor,
Department of Toxicology
Research
Interests: Molecular mechanisms of chemical carcinogenesis;
signal transduction pathways regulating cell growth and squamous
differentiation
James
Stephenson
Adjunct
Assistant Professor, Department of Microbiology
Research
Interests:
Eric
Stone
Assistant
Professor, Department of Statistics
Research
Interests: Developing statistical methods for the analysis of
genomic data; functional inference through the quantification
of evolutionary constraint; predicting mutational tolerance
from sequence variation; estimating the coevolution of continuous
traits
Craig
V. Sullivan
William Neal Reynolds Distinguished Professor,
Department of Zoology
Research
Interests: Reproductive physiology of fishes
William
F. Thompson
University
Research Professor, Department of Plant Biology
Research
Interests: Gene transfer and expression; Chromatin structure
and epigenetic effects; Genetic engineering in plants
Jeffrey
L. Thorne
Professor,
Department of Genetics and Statistics
Research
Interests: The development of statistical tools for the analysis
of DNA and protein sequences
Wayne
A. Tompkins
Professor,
Department of Population Health & Pathobiology
Research
Interests: Molecular characterization of immunopathogenic isolates
of Feline Immunodeficiency Virus and of the host immune response
Anastasios
Tsiatis
Professor,
Department of Statistics
Research
Interests: Design/analysis of clinical trials, censored survival
analysis, group sequential methods, inference on Quality Adjusted
Lifetime, surrogate markers, semiparametric methods with missing
and censored data
Jung-Ying
Tzeng
Assistant
Professor, Department of Statistics
Research
Interests: Statistical methods for studying susceptibility genes
for complex traits, haplotype-similarity methods, haplotype-based
analysis, efficient use of multi-marker information in association
analysis
Paola Veronese
Assistant Professor,
Plant Pathology
Research
Interests:
Mladen
A. Vouk
Professor,
Department of Computer Science
Research
Interests: Application of information theory to genetics; ribosome
memory and signal processing; free energy calculations for genetic
sequences; optimization of cross-species translation
Huixia Judy Wang
Assistant
Professor, Department of Statistics
Research
Interests: Microarray data analysis; DNA content analysis; quantile regression; semiparametric regression; longitudinal data analysis
Ross
Whetten
Associate
Professor, Department of Forestry & Environmental Resources
Research
Interests: Genetic and biochemical mechanisms that integrate
environmental and developmental signals to control xylem formation
in plants
Brian
M. Wiegmann
Professor,
Department of Entomology
Research
Interests: Molecular biosystematics, DNA sequence analysis to
investigate morphological and developmental evolution in family-level
phylogeny of the insect order Diptera (true flies)
Russell
Wolfinger
Adjunct
Professor, Department of Statistics / SAS Institute
Research
Interests: Mixed models for assessing data
Paul
Wollenzien
Professor,
Department of Biochemistry
Research
Interests: RNA structural biology investigated by biochemical
methods, comparative sequence analysis and molecular modeling;
mechanics of the ribosome in protein synthesis
Qiuyun Jenny Xiang
Associate
Professor, Department of Plant Biology
Research
Interest: Plant systematics; biogeography; molecular phylogeny; evolution
Deyu Xie
Assistant
Professor, Plant Biology
Research
Interests: Molecular biology and biochemistry of proanthocyanidin (PA) and anthocyanin biosyntheses, biosynthesis and metabolic engineering of antimalarial drug artemisinin (Qinghaosu, QHS), functional comparative metabolomics of flora
Jeffrey
A. Yoder
Assistant
Professor, Department of Molecular Biomedical Sciences
Research
Interests: Zebrafish immunogenetics; innate immunity; functional
and comparative genomics of immune-related genes; gene discovery
Zhao-Bang
Zeng
William
Neal Reynolds Professor, Department of Statistics and Genetics
Research
Interests: Statistical methods and development of computer software
for mapping quantitative trait loci and for inferring genetic
architecture of quantitative traits in a variety of populations
Daowen
Zhang
Assistant
Professor, Department of Statistics
Research
Interests: Biostatistics, epidemiology and genetics
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